Associations between urinary phytoestrogen mixed metabolites and osteoarthritis risk.

ABSTRACT:

Background

This study aims to explore the relationship between urinary phytoestrogen mixed metabolites and the risk of osteoarthritis (OA).

Methods

Using data from the National Health and Nutrition Examination Survey (NHANES), a Weighted Quantile Sum (WQS) regression analysis was conducted to determine the dominant metabolites. Additionally, a Bayesian kernel machine regression (BKMR) model was utilized to explore the combined effects of phytoestrogen mixed metabolites on OA.

Results

Compared to the lowest quartile group, the highest quartile group of Enterodiol showed a 46% increased risk of OA (OR = 1.46, 95% CI: 1.09-1.96), while the highest quartile group of Enterlactone showed a 30% decreased risk of OA (OR = 0.70, 95% CI: 0.52-0.96). The WQS regression model ana

SUBMITTER: Huang D 

PROVIDER: S-EPMC11563356 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature