Association of the humoral immune response with the inflammatory profile in Plasmodium vivax infections in pregnant women.

ABSTRACT:

Background

Plasmodium vivax infection, when it occurs during pregnancy, has often been associated with serious adverse pregnancy outcomes. However, immunological alterations in pregnancy and their consequences have been little explored. We characterized the humoral immune response in pregnant women exposed to malaria by P. vivax antigens and its association with the maternal inflammatory profile and poor pregnancy outcomes.

Methods

An observational cohort study in the Brazilian Amazon was conducted between 2013 and 2015. After applying exclusion criteria, 242 mother-child pairs were included in the analysis. Data on maternal infection, gestational outcomes, and inflammatory factors were evaluated in the maternal peripheral plasma. In samples from the first infection, the pre

SUBMITTER: Souza RM 

PROVIDER: S-EPMC11563365 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature