A mechanistic model of in vitro plasma activation to evaluate therapeutic kallikrein-kinin system inhibitors.

ABSTRACT:

Background

The kallikrein-kinin system (KKS) is a complex biochemical pathway that plays a crucial role in regulating several physiological processes, including inflammation, coagulation, and blood pressure. Dysregulation of the KKS has been associated with several pathological conditions such as hereditary angioedema (HAE), hypertension, and stroke. Developing an accurate quantitative model of the KKS may provide a better understanding of its role in health and disease and facilitate the rapid and targeted development of effective therapies for KKS-related disorders.

Objectives

Here, we present a novel, detailed mechanistic model of the plasma KKS, elucidating the processes of Factor XII (FXII) activation, the kallikrein feedback loop, cleavage of high molecular weight kini

SUBMITTER: Rezvani-Sharif A 

PROVIDER: S-EPMC11563367 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature