Individualised prediction of major bleeding in patients with atrial fibrillation treated with anticoagulation.

ABSTRACT:

Background

Anticoagulation in atrial fibrillation (AF) increases the risk of major bleeding. No predictive model has hitherto provided estimates of the absolute risk for individual patients.

Aim

To predict the individual 1-year risk of major bleeding in patients with AF taking anticoagulants and evaluate the importance of individual risk factors.

Design

A nationwide register-based cohort study.

Participants

Danish patients with first-time non-valvular AF who redeemed anticoagulants within 7 days after diagnosis.

Method

The individual absolute risk of major bleeding was estimated from a logistic regression model (the Calculator of Absolute Bleeding Risk/CABS model) utilising the same risk factors as HAS-BLED, except allowing non-linear age effects, and al

SUBMITTER: Toft-Petersen AP 

PROVIDER: S-EPMC11563370 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature