Hyper-induction of IL-6 after TLR1/2 stimulation in calves with bovine respiratory disease.

ABSTRACT: Bovine respiratory disease (BRD) is a leading cause of mortality and compromised welfare in bovines. It is a polymicrobial syndrome resulting from a complex interplay of viral and bacterial pathogens with environmental factors. Despite the availability of vaccines, incidence and severity in young calves remains unabated. A more precise analysis of host innate immune responses during infection will identify improved diagnostic and prognostic biomarkers for early intervention and targeted treatments to prevent severe disease and loss of production efficiency. Here, we investigate hematological and innate immune responses using standardized ex-vivo whole blood assays in calves diagnosed with BRD. A total of 65 calves were recruited for this study, all between 2-8 weeks of age with 28 diagnose

SUBMITTER: Reid C 

PROVIDER: S-EPMC11563416 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature