The gut microbiota is essential for Trichinella spiralis-evoked suppression of colitis.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) increases the risk of colorectal cancer, and it has the potential to diminish the quality of life. Clinical and experimental evidence demonstrate protective aspects of parasitic helminth infection against IBD. However, studies on the inhibition of inflammation by helminth infection have overlooked a key determinant of health: the gut microbiota. Although infection with helminths induces alterations in the host microbiota composition, the potential influence and mechanism of helminth infections induced changes in the gut microbiota on the development of IBD has not yet been elucidated. In this study, we analyzed the intersection of helminth Trichinella spiralis and gut bacteria in the regulation of colitis and related mechanisms.

Method

SUBMITTER: Sun H 

PROVIDER: S-EPMC11563474 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature