Capability and accuracy of usual statistical analyses in a real-world setting using a federated approach.

ABSTRACT:

Methods

The objective of this project was to determine the capability of a federated analysis approach using DataSHIELD to maintain the level of results of a classical centralized analysis in a real-world setting. This research was carried out on an anonymous synthetic longitudinal real-world oncology cohort randomly splitted in three local databases, mimicking three healthcare organizations, stored in a federated data platform integrating DataSHIELD. No individual data transfer, statistics were calculated simultaneously but in parallel within each healthcare organization and only summary statistics (aggregates) were provided back to the federated data analyst. Descriptive statistics, survival analysis, regression models and correlation were first performed on the centralized appro

SUBMITTER: Jegou R 

PROVIDER: S-EPMC11563485 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature