Vascular endothelial growth factor/platelet ratio as a potential biomarker for preeclampsia: A study of angiogenic markers in Pakistani patients.

ABSTRACT:

Objectives

To determine the levels of angiogenic biomarkers: vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor 1 (sVEGFR1 or sFlt-1), platelet count, and the VEGF/platelet ratio in preeclampsia.

Methods

Forty-four cases of preeclampsia and 44 controls were recruited.

Results

The serum VEGF, sVEGFR1, and VEGF/platelet ratio were significantly higher and platelet counts lower in preeclampsia in comparison to controls (VEGF: median = 178 vs. 97 pg/mL, p < 0.0001, sVEGFR1: 1634 vs. 627 pg/mL, p < 0.0001, VEGF/platelet ratio: 1.148 vs. 0.417, and platelet count: 178 × 10³/µL vs. 232 × 10³/µL, p = 0.0006). The VEGF and VEGF/platelet ratio showed better diagnostic accuracy for differentia

SUBMITTER: Khidri FF 

PROVIDER: S-EPMC11563536 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature