Astrocytes mediate two forms of spike timing-dependent depression at entorhinal cortex-hippocampal synapses.

ABSTRACT: The entorhinal cortex (EC) connects to the hippocampus sending different information from cortical areas that is first processed at the dentate gyrus (DG) including spatial, limbic and sensory information. Excitatory afferents from lateral (LPP) and medial (MPP) perforant pathways of the EC connecting to granule cells of the DG play a role in memory encoding and information processing and are deeply affected in humans suffering Alzheimer's disease and temporal lobe epilepsy, contributing to the dysfunctions found in these pathologies. The plasticity of these synapses is not well known yet, as are not known the forms of long-term depression (LTD) existing at those connections. We investigated whether spike timing-dependent long-term depression (t-LTD) exists at these two different EC-DG syn

SUBMITTER: Martinez-Gallego I 

PROVIDER: S-EPMC11563576 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature