Methodology of comparative studies on the relative effectiveness of COVID-19 vaccines: a systematic review.

ABSTRACT:

Background

This study aimed to comprehensively outline the methodological approaches used in published research comparing the vaccine effectiveness (VE) of coronavirus disease 2019 (COVID-19) vaccines.

Methods

A systematic search was conducted on June 13, 2024, to identify comparative studies evaluating the effectiveness of mRNA versus non-mRNA and monovalent versus bivalent COVID-19 vaccines. We screened titles, abstracts, and full texts, collecting data on publication year, country, sample size, study population composition, study design, VE estimates, outcomes, and covariates. Studies that reported relative VE (rVE) were analyzed separately from those that did not.

Results

We identified 25 articles comparing rVE between mRNA and non-mRNA COVID-19 vaccines, as well

SUBMITTER: Bolormaa E 

PROVIDER: S-EPMC11563719 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature