Molecular characteristics of drug-susceptible Mycobacterium tuberculosis clinical isolates based on treatment duration.

ABSTRACT:

Background

In this study, we performed comparative genomic and transcriptomic analysis of clinical isolates of Mycobacterium tuberculosis collected from patients with drug-susceptible tuberculosis (DS-TB). The clinical isolates were categorized based on treatment duration: standard 6 months or >6 months.

Methods

Study participants were recruited from a 2016 to 2018 tuberculosis cohort, and clinical M. tuberculosis isolates were collected from the sputum of patients with tuberculosis. We analyzed the genome and transcriptome of the isolated M. tuberculosis.

Results

Genomic analysis revealed a specific non-synonymous single-nucleotide polymorphism in pe_pgrs9 and ppe34, exclusive to the group treated for >6 months. Transcriptomic analysis revealed increased expression o

SUBMITTER: Ko EM 

PROVIDER: S-EPMC11563727 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature