RIG012 assists in the treatment of pneumonia by inhibiting the RIG-I-like receptor signaling pathway.

ABSTRACT:

Objective

Pneumonia is a common clinical condition primarily treated with antibiotics and organ support. Exploring the pathogenesis to identify therapeutic targets may aid in the adjunct treatment of pneumonia and improve survival rates.

Methods

Transcriptomic data from peripheral blood of 183 pneumonia patients were analyzed using Gene Set Variation Analysis (GSVA) and univariate Cox regression analysis to identify signaling pathways associated with pneumonia mortality. A pneumonia mouse model was established via airway injection of Klebsiella pneumoniae, and pathway-specific blockers were administered via tail vein infusion to assess whether the identified signaling pathways impact the mortality in pneumonia.

Results

The combination of GSVA and Cox analysis r

SUBMITTER: Zhang S 

PROVIDER: S-EPMC11563779 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature