Transcriptome analysis revealed the genes and major pathways involved in prunetrin treated hepatocellular carcinoma cells.

ABSTRACT: Liver cancer represents a complex and severe ailment that poses tough challenges to global healthcare. Transcriptome sequencing plays a crucial role in enhancing our understanding of cancer biology and accelerating the development of more effective methods for cancer diagnosis and treatment. In the course of our current investigation, we identified a total of 1,149 differentially expressed genes (DEGs), encompassing 499 upregulated and 650 downregulated genes, subsequent to prunetrin (PUR) treatment. Our methodology encompassed gene and pathway enrichment analysis, functional annotation, KEGG pathway assessments, and protein-protein interaction (PPI) analysis of the DEGs. The preeminent genes within the DEGs were found to be associated with apoptotic processes, cell cycle regulation, the P

SUBMITTER: Abusaliya A 

PROVIDER: S-EPMC11563786 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature