Plasma proteome profiling in giant cell arteritis.

ABSTRACT:

Objectives

This study aimed to identify plasma proteomic signatures that differentiate active and inactive giant cell arteritis (GCA) from non-disease controls. By comprehensively profiling the plasma proteome of both patients with GCA and controls, we aimed to identify plasma proteins that (1) distinguish patients from controls and (2) associate with disease activity in GCA.

Methods

Plasma samples were obtained from 30 patients with GCA in a multi-institutional, prospective longitudinal study: one captured during active disease and another while in clinical remission. Samples from 30 age-matched/sex-matched/race-matched non-disease controls were also collected. A high-throughput, aptamer-based proteomics assay, which examines over 7000 protein features, was used to generate

SUBMITTER: Cunningham KY 

PROVIDER: S-EPMC11563890 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature