Risk factors and clinical prediction models for low-level viremia in people living with HIV receiving antiretroviral therapy: an 11-year retrospective study.

ABSTRACT:

Objective

This study explores the risk factors for low-level viremia (LLV) occurrence after ART and develops a risk prediction model.

Method

Clinical data and laboratory indicators of people living with HIV (PLWH) at Hangzhou Xixi Hospital from 5 April 2011 to 29 December 2022 were collected. LASSO Cox regression and multivariate Cox regression analysis were performed to identify laboratory indicators and establish a nomogram for predicting LLV occurrence. The nomogram's discrimination and calibration were assessed via ROC curve and calibration plots. The concordance index (C-index) and decision curve analysis (DCA) were used to evaluate its effectiveness.

Result

Predictive factors, namely, age, ART delay time, white blood cell (WBC) count, baseline CD4⁺ T-

SUBMITTER: Zhang W 

PROVIDER: S-EPMC11563986 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature