Predictive model for aminoglycoside induced ototoxicity.

ABSTRACT:

Background

Irreversible hearing loss is a well-known adverse effect of aminoglycosides, however, inability to accurately predict ototoxicity is a major limitation in clinical care. We addressed this limitation by developing a prediction model for aminoglycoside ototoxicity applicable to the general population.

Methods

We employed a prospective non-drug-resistant tuberculosis (TB), non-HIV/AIDS cohort of 153 adults on Streptomycin based anti-TB therapy. High frequency pure-tone audiometry was done at regular intervals throughout the study. Clinical and audiological predictors of ototoxicity were collated and ototoxic threshold shift from the baseline audiogram computed. The prediction model was developed with logistic regression method by examining multiple predictors of otot

SUBMITTER: Adeyemo AA 

PROVIDER: S-EPMC11563990 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature