Intrapartum antibiotic exposure and infectious diseases in childhood - a population-based cohort study.

ABSTRACT:

Background

Intrapartum antibiotics are used to prevent group B streptococcus disease in newborn infants. We hypothesised that intrapartum antibiotic exposure is associated with the occurrence of childhood infectious diseases because it influences the development of the gut microbiome.

Methods

The cohort for this population-based study comprised vaginally delivered children born in Northern Finland in 2007-2018. We used structured electronic medical records linked to comprehensive national registers. Primary outcome was the number of infectious disease episodes leading to an emergency room visit, outpatient hospital visit, or hospitalisation from birth until five years of age.

Findings

Analyses were performed on 9733 children (48.8% girls) exposed to intrapartum antibi

SUBMITTER: Hakkola M 

PROVIDER: S-EPMC11563998 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature