NaCTR: Natural product-derived compound-based drug discovery pipeline from traditional oriental medicine by search space reduction.

ABSTRACT: The drug discovery pipelines require enormous time and cost, albeit their infamously high risk of failures. Reducing such risk has therefore been the utmost goal in the process. Recently, natural products (NPs) in traditional oriental medicine (TOM) have come into the spotlight for their efficacy and safety supported throughout the history. Not only that, with the ever-increasing repository of various biological datasets, many data-driven in silico approaches have also been extensively studied for better efficient search and testing. However, TOM-based datasets lack information on recently prevalent diseases, while experimental datasets are prone to provide target spaces that are too large. Adequate combination of both approaches can therefore fill in each other's blanks. In this st

SUBMITTER: Jung S 

PROVIDER: S-EPMC11564001 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature