Regulatory roles of NAMPT and NAD⁺ metabolism in uterine leiomyoma progression: Implications for ECM accumulation, stemness, and microenvironment.

ABSTRACT: Uterine leiomyoma (UL), commonly referred to as benign tumors, is characterized by excessive cell proliferation, extracellular matrix (ECM) accumulation, and the presence of stem cell-like properties. Nicotinamide adenine dinucleotide (NAD⁺) metabolism, regulated in part by nicotinamide phosphoribosyltransferase (NAMPT), plays a crucial role in these pathological processes and has emerged as a potential therapeutic target. Additionally, redox signaling pathways are integral to the pathogenesis of UL, influencing the dynamics of NAD⁺ metabolism. This study sought to elucidate the regulatory functions of NAMPT and NAD⁺ metabolism, in conjunction with redox signaling, in the progression of UL, and to explore potential therapeutic strategies targeting these pat

SUBMITTER: Chiang YF 

PROVIDER: S-EPMC11564007 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature