IMM2520, a novel anti-CD47/PD-L1 bispecific antibody for cancer immune therapy.

ABSTRACT: PD-1/PD-L1 is an important signaling pathway in the adaptive immune system. The CD47/SIRPα signaling pathway is a crucial "do not eat me" signal for innate immunity. This study evaluated the anti-tumor mechanism of IMM2520 in vitro and in vivo. IMM2520 was generated using the "mab-trap" platform. IMM2520 showed high affinity to PD-L1 and relatively lower affinity to CD47, displaying preferential binding to PD-L1 on tumor cells. IMM2520 had the potent ability to inhibit the PD-1/PD-L1 and CD47/SIRPα signaling pathways and killed tumor cells through ADCC and ADCP. Importantly, IMM2520 did not bind to human red blood cells or induce erythrocyte agglutination. IMM2520 demonstrated a tendency to bind to CD47⁺/PD-L1⁺ tumor cells, reducing its binding to CD47 s

SUBMITTER: Yang C 

PROVIDER: S-EPMC11564011 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature