Rare Event Approximation Between Subdistribution Hazard Ratio and Cause-specific Hazard Ratio in Survival Analysis With Competing Risks.

ABSTRACT:

Background

Despite the fact that competing risks are inevitable in epidemiological and clinical studies, distinctions between the hazard ratio estimated by handling competing risks as censoring and the subditribution hazard ratio are often overlooked.

Methods

We derived quantitative relationships between subdistribution hazard ratio and cause-specific hazard ratio and derive an approximate calculation method to transform the two into each other. Numerical examinations of hypothetical six scenarios and published information of a randomized clinical trial of cholesterol-lowering therapy and a registry of acute myeloid leukemia were provided.

Results

General and approximate relationships under rare event assumptions between the two types of hazard ratio were given. The a

SUBMITTER: Tanaka S 

PROVIDER: S-EPMC11564069 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature