Endogenous innate sensor NLRP3 is a key component in peritoneal macrophage dynamics required for cestode establishment.

ABSTRACT: The NLRP3 receptor can assemble inflammasome platforms to trigger inflammatory responses; however, accumulating evidence suggests that it can also display anti-inflammatory properties. Here, we explored the role of nucleotide-binding oligomerization domain pyrin-containing protein 3 (NLRP3) in Taenia crassiceps experimental infection, which requires immune polarization into a Th2-type profile and peritoneal influx of suppressive macrophages for successful colonization. NLRP3 deficient mice (NLRP3^-/-) were highly resistant against T. crassiceps, relative to wild-type (WT) mice. Resistance in NLRP3^-/- mice was associated with a diminished IL-4 output, high levels of IL-15, growth factor for both innate and adaptive lymphocytes, and a dramatic decrease in peritoneum-infi

SUBMITTER: Flores-Sotelo I 

PROVIDER: S-EPMC11564225 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature