Alterations of gut microbiome in eosinophilic chronic rhinosinusitis.

ABSTRACT:

Purpose

A growing body of evidence has elucidated that the gut microbiota has a crucial impact on the pathophysiological process of atopic diseases. Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is a local atopic disease of the systemic immune response. Alterations in the gut microbiome in eCRSwNP patients remain largely undefined.

Methods

16S rRNA gene sequencing was performed in a cross-sectional study of 17 eCRSwNP patients, 9 noneCRSwNP patients and 13 healthy controls, and gut microbiota DNA sequencing between each pair of groups was compared using bioinformatic methods.

Results

Compared with that of healthy controls, the gut microbiomes of eCRSwNP patients were characterised by a distinct overall microbial composition. However, no significant d

SUBMITTER: Liang Y 

PROVIDER: S-EPMC11564334 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature