A systematic approach to determine the outcome of the competition between two microbial species in bioreactor cocultures.

ABSTRACT: The two-species microbial cocultures are effective in terms of awakening the cryptic biosynthetic pathways. They may also lead to the improved production of previously discovered molecules. Importantly, only a few outcomes of the cocultures may prove desirable, namely those leading to the formation of useful secondary metabolites. To address this issue, a method allowing for the evaluation of the final outcome of the co-culture process and fine-tune the cocultivation strategy was proposed. The systematic approach was supported by the experimental data from the bioreactor runs with the participation of Aspergillus terreus and Penicillium rubens confronted with Streptomyces rimosus and Streptomyces noursei. Kinetic, morphological and metabolic aspects of dominance were analysed via the newly

SUBMITTER: Bizukojc M 

PROVIDER: S-EPMC11564368 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature