AI tool for predicting MGMT methylation in glioblastoma for clinical decision support in resource limited settings.

ABSTRACT: Glioblastoma is an aggressive brain cancer with a poor prognosis. The O6-methylguanine-DNA methyltransferase (MGMT) gene methylation status is crucial for treatment stratification, yet economic constraints often limit access. This study aims to develop an artificial intelligence (AI) framework for predicting MGMT methylation. Diagnostic magnetic resonance (MR) images in public repositories were used for training. The algorithm created was validated in data from a single institution. All images were segmented according to widely used guidelines for radiotherapy planning and combined with clinical evaluations from neuroradiology experts. Radiomic features and clinical impressions were extracted, tabulated, and used for modeling. Feature selection methods were used to identify relevant phenot

SUBMITTER: Restini FCF 

PROVIDER: S-EPMC11564566 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature