Sex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke.

ABSTRACT: Introduction: Females suffer greater lifetime risk of stroke and greater morbidity and mortality from stroke compared with males. This study's objective was to identify differences in metabolomic profiling of females and males with stroke and which differences were associated with neurological outcome. Methods: Females and males with acute ischemic stroke enrolled in the Emergency Medicine Specimen Bank at a comprehensive stroke center provided whole blood samples upon arrival for mass spectrometry-based metabolomics. We used descriptive statistics to characterize the cohort. A linear regression model was fit for individual metabolites to determine differences in relative abundance between males and females while controlling for covariates (age, race/ethnicity,

SUBMITTER: Dylla L 

PROVIDER: S-EPMC11564668 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature