Break-up and recovery of harmony between direct and indirect pathways in the basal ganglia: Huntington's disease and treatment.

ABSTRACT: The basal ganglia (BG) in the brain exhibit diverse functions for motor, cognition, and emotion. Such BG functions could be made via competitive harmony between the two competing pathways, direct pathway (DP) (facilitating movement) and indirect pathway (IP) (suppressing movement). As a result of break-up of harmony between DP and IP, there appear pathological states with disorder for movement, cognition, and psychiatry. In this paper, we are concerned about the Huntington's disease (HD), which is a genetic neurodegenerative disorder causing involuntary movement and severe cognitive and psychiatric symptoms. For the HD, the number of D2 SPNs ( ND2 ) is decreased due to degenerative loss, and hence, by decreasing xD2 (fraction of ND2 ), we investigate break-up of harmony between DP and IP i

SUBMITTER: Kim SY 

PROVIDER: S-EPMC11564723 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature