Discriminating Parkinson's disease patients from healthy controls using nasal respiratory airflow.

ABSTRACT:

Background

Breathing patterns may inform on health. We note that the sites of earliest brain damage in Parkinson's disease (PD) house the neural pace-makers of respiration. We therefore hypothesized that ongoing long-term temporal dynamics of respiration may be altered in PD.

Methods

We applied a wearable device that precisely logs nasal airflow over time in 28 PD patients (mostly H&Y stage-II) and 33 matched healthy controls. Each participant wore the device for 24 h of otherwise routine daily living.

Results

We observe significantly altered temporal patterns of nasal airflow in PD, where inhalations are longer and less variable than in matched controls (mean PD = -1.22 ± 1.9 (combined respiratory features score), Control = 1.04 ± 2.16, Wilcoxon rank-sum test, z = -4

SUBMITTER: Andelman-Gur M 

PROVIDER: S-EPMC11564766 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature