Fecal microbiota transplantation alleviates cognitive impairment by improving gut microbiome composition and barrier function in male rats of traumatic brain injury following gas explosion.

ABSTRACT:

Background

Dysbiosis of gut microbiota (GM) is intricately linked with cognitive impairment and the incidence of traumatic brain injury (TBI) in both animal models and human subjects. However, there is limited understanding of the impact and mechanisms of fecal microbiota transplantation (FMT) on brain and gut barrier function in the treatment of TBI induced by gas explosion (GE).

Methods

We have employed FMT technology to establish models of gut microbiota dysbiosis in male rats, and subsequently conducted non-targeted metabolomics and microbiota diversity analysis to explore the bacteria with potential functional roles.

Results

Hematoxylin-eosin and transmission electron microscopy revealed that GE induced significant pathological damage and inflammation responses,

SUBMITTER: Dong X 

PROVIDER: S-EPMC11564976 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature