Association between prenatal maternal sleep quality, neonatal uncinate fasciculus white matter, and infant negative emotionality.

ABSTRACT:

Background

Poor prenatal maternal sleep is a pervasive, yet modifiable, health concern affecting maternal and foetal wellbeing. Experimental rodent studies demonstrate that prenatal maternal sleep deprivation affects offspring brain development and leads to adverse outcomes, including increased anxiety-like behaviour. We examined the relation between prenatal maternal sleep quality and neonatal white matter development and subsequent infant negative emotionality.

Methods

Participants included 116 mother-infant (53% female) dyads. Prenatal sleep quality was prospectively assessed three times during gestation (16, 29, and 35 gestational weeks) using the Pittsburgh Sleep Quality Index. Neonatal white matter, as indexed by fractional anisotropy (FA), was assessed via diffusion w

SUBMITTER: Nevarez-Brewster M 

PROVIDER: S-EPMC11564983 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature