Evaluating the mitochondrial structure and gene expression profile of regenerated liver tissues in mice after 85% partial hepatectomy.

ABSTRACT:

Background

Partial hepatectomy (PH) is the primary method used for treating liver injury and transplantation. The regeneration process after hepatectomy requires an adequate energy supply, and mitochondria serve as the primary source of energy. Alterations in genes related to the respiratory chain complex may impact the liver regeneration process. The aim of this study was the changes in mitochondrial structure and mitochondrial function in 85% PH.

Methods

A PH (up to 85%) model was developed using male C57BL/6 mice, and the regenerated liver tissue was harvested after 24 hours. Hematoxylin and eosin staining and transmission electron microscopy were used for morphological studies. In terms of proliferation, a positive proliferating cell nuclear antigen (PCNA) rate was detec

SUBMITTER: Shi Y 

PROVIDER: S-EPMC11565125 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature