Regioselective bromination of pyrrolo[1,2-<i>a</i>]quinoxalines.

ABSTRACT: In this study, we report a novel and efficient method for the regioselective bromination of pyrrolo[1,2-a]quinoxalines using tetrabutylammonium tribromide (TBATB). This method exploits the mild nature of TBATB to obtain highly selective C3-brominated or C1, C3-dibrominated products in good yields. Notably, the reaction has a broad substrate applicability, and the C3-brominated product can be synthesized on a gram scale and can be further converted into structurally diverse pyrrolo[1,2-a]quinoxaline derivatives.

SUBMITTER: Li Y 

PROVIDER: S-EPMC11565163 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature