Eighteen genes primarily expressed in the testis are not required for male fertility in mice†.

ABSTRACT: There are approximately 20 000 protein-coding genes in humans and mice. More than 1000 of these genes are predominantly expressed in the testis or are testis-specific and thought to play an important role in male reproduction. Through the production of gene knockout mouse models and phenotypic evaluations, many genes essential for spermatogenesis, sperm maturation, and fertilization have been discovered, greatly contributing to the elucidation of their molecular mechanisms. On the other hand, there are many cases in which single-gene knockout models do not affect fertility, indicating that tissue-specific genes are not always critical. Here, we selected 18 genes whose mRNA expression is restricted to the testis or higher than in other tissues, but whose function in male reproduction is unk

SUBMITTER: Yamamoto K 

PROVIDER: S-EPMC11565233 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature