First Trimester Tetracycline Exposure and Risk of Major Congenital Malformations.

ABSTRACT:

Importance

Safety data on tetracycline antibiotic use during pregnancy are limited.

Objective

To investigate the association between first trimester exposure to tetracyclines and the risk of major congenital malformations (MCMs).

Design, setting, and participants

This cohort study used data from nationwide registers for singleton infants live-born in Sweden from July 1, 2006, to December 31, 2018, with follow-up through December 2019. Tetracycline-exposed and unexposed infants were matched on propensity scores (ratio 1:10). Data analysis was performed from June 2023 to May 2024.

Exposure

First trimester exposure to tetracyclines determined from maternal prescription fills, compared with no exposure.

Main outcomes and measures

The primary outcome was any

SUBMITTER: Nakitanda AO 

PROVIDER: S-EPMC11565264 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature