Statistical power and sample size requirements to detect an intervention by time interaction in four-level longitudinal cluster randomized trials.

ABSTRACT: Cluster/group randomized controlled trials (CRTs) have a long history in the study of health sciences. CRT is a special type of intervention trial in which a complete group is randomly assigned to a study condition (or intervention). It is typically performed when individual randomization is difficult/impossible without substantial risk of contamination across study arms or prohibitive from the cost or group dynamics point of view. In this article, the aim is to design and analyze four-level longitudinal cluster randomized trials. The main interest here is to study the difference between treatment groups over time for such a four-level hierarchical data structure. This work is motivated by a real-life study for education based HIV prevention. Such trials are not only popular for administra

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC11565273 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature