Patient-reported assessments of chronic cough in clinical trials: accessory or primary endpoints?

ABSTRACT: Chronic cough is a complex disorder that affects up to 5-10% of the general population. It can be challenging to manage as there are few effective treatments, although several novel antitussives are in clinical development. The endpoints used to assess their efficacy in clinical trials should be optimal; most large clinical trials currently use objective measures as the primary outcome, especially cough frequency. There are strengths in this approach, although taking the view that other measures of chronic cough are less important, including patient-rated cough severity, psychosocial impact and other associated symptoms. Patient-reported outcome measures (PROMs) explore patients' personal experiences of health and disease, and the effects of particular conditions on their lives. Numerous v

SUBMITTER: Mackay EC 

PROVIDER: S-EPMC11565313 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature