Anticoagulant therapy in adult with COVID-19: a systematic review and meta-analysis of randomized controlled trial.

ABSTRACT:

Background

Blood coagulation dysfunction is a risk factor for adverse outcomes in patients with coronavirus disease 2019 (COVID-19), especially in severe cases. The evidence for the effects of anticoagulation therapy on prognosis of COVID-19 patients and its risk of causing bleeding events is accumulating. Here we conducted a meta-analysis to assess the efficacy and safety of anticoagulants in COVID-19 patients of different severity.

Methods

We searched PubMed, Embase databases, Cochrane Trials, OVID MEDLINE from December 2019 to April 2023. We included randomized controlled trials (RCTs) involving COVID-19 patients over 18 years of age, which explored the effect of anticoagulant and its dose on outcomes including all-cause mortality, bleeding events or thrombotic events. We

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC11565368 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature