Proinsulin C-peptide is a major source of HLA-DQ8 restricted hybrid insulin peptides recognized by human islet-infiltrating CD4⁺ T cells.

ABSTRACT: Type 1 diabetes (T1D) is an autoimmune disease that develops when T cells destroy the insulin-producing beta cells that reside in the pancreatic islets. Immune cells, including T cells, infiltrate the islets and gradually destroy the beta cells. Human islet-infiltrating CD4⁺ T cells recognize peptide epitopes derived from proinsulin, particularly C-peptide. Hybrid insulin peptides (HIPs) are neoepitopes formed by the fusion of two peptides derived from beta cell granule proteins and are known to be the targets of pathogenic CD4⁺ T cells in the non-obese diabetic (NOD) mouse and human islet-infiltrating CD4⁺ T cells. Proinsulin is widely recognized as a central antigen in T1D, but its role in forming HIPs is unclear. We developed a method to functionally scr

SUBMITTER: Bhattacharjee P 

PROVIDER: S-EPMC11565411 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature