Integrated analysis of multi-omics data for the discovery of biomarkers and therapeutic targets for juvenile idiopathic arthritis.

ABSTRACT:

Background

Juvenile idiopathic arthritis (JIA) is a prevalent chronic rheumatic disease affecting children. Current medications merely alleviate symptoms rather than curing the disease. Hence, the identification and development of novel drug targets and biomarkers for JIA are imperative for enhancing treatment efficacy.

Methods

We employed two-sample Mendelian randomization (MR) analysis to investigate the causal effects of plasma proteins on JIA. Additionally, colocalization, bulk RNA-seq, and single-cell RNA-seq analyses were conducted to further investigate and validate the potential of candidate proteins as drug targets.

Results

Through MR analysis, we successfully identified five plasma proteins that are causally linked to JIA. Genetically inferred lower levels o

SUBMITTER: Cai YX 

PROVIDER: S-EPMC11565427 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature