Profiling patent compounds in lipid nanoparticle formulations of siRNA.

ABSTRACT: Lipid nanoparticles (LNPs) have emerged as a prominent delivery system for nucleic acid drugs, attracting significant attention, especially through the successful development of several commercial products. As a key component in LNPs, cationic lipids have long served as a key technical barrier to block competitors by building up a complex patent thicket. However, there have been few studies as yet that have comprehensively analyzed the patented compounds in LNP formulations, despite a large number of technical reviews and original articles. In this context, this study focuses on analyzing the macroscopic landscapes and microscopic molecular characteristics of LNP patents, aiming to provide a valuable reference for researchers and developers in making informed technological and commercial d

SUBMITTER: Han Y 

PROVIDER: S-EPMC11565460 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature