COVID-19 infection-induced worsening of recurrent CK-MB isozyme elevation due to macro-CK type 1 in a child: case report.

ABSTRACT:

Background

Macro-creatine kinase (macro-CK) type 1, a macroenzyme composed of creatine kinase (CK) and immunoglobulin, is associated with hypothyroidism, tumour, autoimmune diseases, myositis, and cardiovascular diseases, and may even be found in the absence of associated pathology. However, its relationship with coronavirus disease (COVID-19) infection remains unreported.

Case summary

An 11-year-old male patient presented with recurrent myocardial enzyme abnormalities, mainly manifested as elevated activities of CK and CK isoenzyme [particularly CK-myocardial band (MB)] with activity inverse (CK-MB higher than CK). Dynamic examinations revealed a continuous increase in CK-MB activity closely related to infection, peaking immediately after COVID-19 infection (CK 1838 U/L and

SUBMITTER: Zhang C 

PROVIDER: S-EPMC11565584 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature