Assessing the use of blood microRNA expression patterns for predictive diagnosis of myxomatous mitral valve disease in dogs.

ABSTRACT:

Background

Myxomatous mitral valve disease (MMVD) is a common, acquired, and progressive canine heart disease. The presence of heart murmur and current cardiac biomarkers are useful in MMVD cases but are not sufficiently discriminatory for staging an individual patient.

Objectives

This study aimed to conduct a preliminary assessment of canine serum and plasma expression profiles of 15 selected miRNA markers for accurate discrimination between MMVD patients and healthy controls. Additionally, we aim to evaluate the effectiveness of this method in differentiating between pre-clinical (stage B1/B2) and clinical (stage C/D) MMVD patients.

Animals

Client-owned dogs (n = 123) were recruited for the study. Following sample exclusions (n = 26), healthy controls

SUBMITTER: Palarea-Albaladejo J 

PROVIDER: S-EPMC11565599 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature