Alterations of Gut Microbiome Composition and Function Pre- and Post-Adenotonsillectomy in Children with Obstructive Sleep Apnea.

ABSTRACT:

Importance

Obstructive sleep apnea (OSA) in children is linked with alterations in the gut microbiome. The influence of adenotonsillectomy (AT), a primary intervention for OSA, on gut microbiota dynamics relative to disease severity remains to be elucidated.

Objective

This study aimed to investigate the impact of OSA severity and AT on the gut microbiome in pediatric patients.

Design

A prospective observational study.

Setting

Tertiary referral center.

Participants

A cohort of 55 pediatric patients treated with AT for OSA.

Intervention

Total tonsillectomy and adenoidectomy procedures.

Main outcome measures

Comprehensive evaluations included in-laboratory polysomnography and 16S rRNA gut microbiome profiling at baseline, and again at 3rd and

SUBMITTER: Chuang HH 

PROVIDER: S-EPMC11565609 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature