Quantitative DCE Dynamics on Transformed MR Imaging Discriminates Clinically Significant Prostate Cancer.

ABSTRACT: Dynamic contrast enhancement (DCE) imaging is a valuable sequence of multiparametric magnetic resonance imaging (mpMRI). A DCE sequence enhances the vasculature and complements T2-weighted (T2W) and Diffusion-weighted imaging (DWI), allowing early detection of prostate cancer. However, DCE assessment has remained primarily qualitative. The study proposes quantifying DCE characteristics (T1W sequences) using six time-dependent metrics computed on feature transformations (306 radiomic features) of abnormal image regions observed over time. We applied our methodology to prostate cancer patients with the DCE MRI images (n = 25) who underwent prostatectomy with confirmed pathological assessment of the disease using Gleason Score. Regions of abnormality were assessed on the T2W MRI, guided using

SUBMITTER: Wei Z 

PROVIDER: S-EPMC11565616 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature