Identification of hub fatty acid metabolism-related genes and immune infiltration in IgA nephropathy.

ABSTRACT:

Aims

To investigate the potential mechanisms of fatty acid metabolism (FAM)-related genes in IgA nephropathy (IgAN) and to explore its immune cell infiltration characteristic.

Methods

Datasets for IgAN and FAM-related genes were obtained from GEO and MSigDB database, respectively. We employed differential expression analysis and WGCNA to identify common genes. GO and KEGG analyses were performed to compare the differences between IgAN and control groups. Furthermore, LASSO logistic regression was applied to develop a predictive model based on FAM-related genes. The efficacy of this prognostic model was evaluated using ROC analysis. The infiltration of immune cells and immune-related functions were assessed with CIBERSORT tool. Finally, the identified key genes were validated

SUBMITTER: Qian X 

PROVIDER: S-EPMC11565677 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature