Transcriptional phenotype of the anti-parasitic benzodiazepine meclonazepam on the blood fluke <i>Schistosoma mansoni</i>.

ABSTRACT: There are limited control measures for the disease schistosomiasis, despite the fact that infection with parasitic blood flukes affects hundreds of millions of people worldwide. The current treatment, praziquantel, has been in use since the 1980's and there is a concern that drug resistance may emerge with continued monotherapy. Given the need for additional antischistosomal drugs, we have re-visited an old lead, meclonazepam. In comparison to praziquantel, there has been relatively little work on its antiparasitic mechanism. Recent findings indicate that praziquantel and meclonazepam act through distinct receptors, making benzodiazepines a promising chemical series for further exploration. Previous work has profiled the transcriptional changes evoked by praziquantel treatment. Here, we ex

SUBMITTER: Henthorn CR 

PROVIDER: S-EPMC11565718 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature