Non-allometric expansion and enhanced compartmentalization of Purkinje cell dendrites in the human cerebellum.

ABSTRACT: Purkinje cell (PC) dendrites are optimized to integrate the vast cerebellar input array and drive the sole cortical output. PCs are classically seen as stereotypical computational units, yet mouse PCs are morphologically diverse and those with multi-branched structure can receive non-canonical climbing fiber (CF) multi-innervation that confers independent compartment-specific signaling. While otherwise uncharacterized, human PCs are universally multi-branched. Do they exceed allometry to achieve enhanced integrative capacities relative to mouse PCs? To answer this, we used several comparative histology techniques in adult human and mouse to analyze cellular morphology, parallel fiber (PF) and CF input arrangement, and regional PC demographics. Human PCs are substantially larger than previo

SUBMITTER: Busch SE 

PROVIDER: S-EPMC11565726 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature