Pervasive fitness trade-offs revealed by rapid adaptation to shifting population densities in large experimental populations of <i>Drosophila melanogaster</i>.

ABSTRACT: Trade-offs are an inherent feature of organismal biology that are expected play a fundamental role in the evolution of natural populations. Efforts to quantify trade-offs are largely confined to phenotypic measurements and the identification of negative genetic-correlations among fitness-relevant traits. Here, we use time-series genomic data collected during experimental evolution in large, genetically diverse populations of Drosophila melanogaster to directly measure the manifestation of trade-offs in response to fluctuating selection on ecological timescales. Specifically, we first conducted a lab-based selection experiment to quantify a genome-wide signal of antagonistic pleiotropy elicited in response to shifting population densities and associated with reproduction and stress t

SUBMITTER: Bitter MC 

PROVIDER: S-EPMC11565731 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature