Breast tumor microbiome regulates anti-tumor immunity and T cell-associated metabolites.

ABSTRACT:

Background

Breast cancer, the most common cancer type among women, was recently found to contain a specific tumor microbiome, but its impact on host biology remains unclear. CD8⁺ tumor-infiltrating lymphocytes (TILs) are pivotal effectors of anti-tumor immunity that influence cancer prognosis and response to therapy. This study aims to elucidate interactions between CD8⁺ TILs and the breast tumor microbiome and metabolites, as well as how the breast tumor microbiome may affect the tumor metabolome.

Methods

We investigated the interplay among CD8⁺ TILs, the tumor microbiome, and the metabolome in a cohort of 46 breast cancer patients with mixed subtypes (Cohort A). We characterized the tumor metabolome by mass spectrometry and CD8⁺

SUBMITTER: Liu CC 

PROVIDER: S-EPMC11565759 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature