Structure elucidation, biosynthetic gene cluster distribution, and biological activities of ketomemicin analogs in <i>Salinispora</i>.

ABSTRACT: We report three new ketomemicin pseudopeptides (1-3) from extracts of the marine actinomycete Salinispora pacifica strain CNY-498. Their constitution and relative configuration were elucidated using NMR, mass spectrometry, and quantum chemical calculations. Using GNPS molecular networking and publicly available Salinispora LCMS datasets, five additional ketomemicin analogs (4-8) were identified with ketomemicin production detected broadly across Salinispora species. The ketomemicin biosynthetic gene cluster (ktm) is highly conserved in Salinispora, occurring in 79 of 118 public genome sequences including eight of the nine named species. Outside Salinispora, ktm homologs were detected in various genera of the phylum Actin

SUBMITTER: Castro-Falcon G 

PROVIDER: S-EPMC11565770 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature